PUBLICATION

Exome sequencing identifies NBEAL2 as the causative gene for gray platelet syndrome

Authors
Albers, C.A., Cvejic, A., Favier, R., Bouwmans, E.E., Alessi, M.C., Bertone, P., Jordan, G., Kettleborough, R.N., Kiddle, G., Kostadima, M., Read, R.J., Sipos, B., Sivapalaratnam, S., Smethurst, P.A., Stephens, J., Voss, K., Nurden, A., Rendon, A., Nurden, P., and Ouwehand, W.H.
ID
ZDB-PUB-110719-42
Date
2011
Source
Nature Genetics   43(8): 735-7 (Journal)
Registered Authors
Kettleborough, Ross
Keywords
none
MeSH Terms
  • Base Sequence
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/metabolism
  • Adult
  • Aged
  • Male
  • Gene Expression Regulation, Developmental
  • Blood Platelets/metabolism*
  • Blood Platelets/pathology
  • Female
  • Cytoplasmic Granules/metabolism*
  • Middle Aged
  • Animals
  • Zebrafish/growth & development
  • Zebrafish/metabolism
  • Molecular Sequence Data
  • Animals, Genetically Modified
  • Secretory Vesicles/metabolism*
  • Young Adult
  • Sequence Analysis, DNA
  • Gray Platelet Syndrome/genetics*
  • Sequence Homology, Nucleic Acid
  • Pedigree
  • Humans
  • Nerve Tissue Proteins/antagonists & inhibitors
  • Nerve Tissue Proteins/genetics*
PubMed
21765411 Full text @ Nat. Genet.
Abstract
Gray platelet syndrome (GPS) is a predominantly recessive platelet disorder that is characterized by mild thrombocytopenia with large platelets and a paucity of α-granules; these abnormalities cause mostly moderate but in rare cases severe bleeding. We sequenced the exomes of four unrelated individuals and identified NBEAL2 as the causative gene; it has no previously known function but is a member of a gene family that is involved in granule development. Silencing of nbeal2 in zebrafish abrogated thrombocyte formation.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping