PUBLICATION
The biological role of the glycinergic synapse in early zebrafish motility
- Authors
- Hirata, H., Takahashi, M., Yamada, K., and Ogino, K.
- ID
- ZDB-PUB-110701-6
- Date
- 2011
- Source
- Neuroscience research 71(1): 1-11 (Journal)
- Registered Authors
- Hirata, Hiromi
- Keywords
- zebrafish, mutant, glycine, synapse, receptor, transporter
- MeSH Terms
-
- Animals
- Glycine/genetics
- Glycine/physiology*
- Motor Activity/genetics
- Motor Activity/physiology*
- Receptors, Glycine/genetics
- Receptors, Glycine/physiology
- Synapses/genetics
- Synapses/physiology*
- Zebrafish/genetics
- Zebrafish/physiology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/physiology*
- PubMed
- 21712054 Full text @ Neurosci. Res.
Citation
Hirata, H., Takahashi, M., Yamada, K., and Ogino, K. (2011) The biological role of the glycinergic synapse in early zebrafish motility. Neuroscience research. 71(1):1-11.
Abstract
Glycine mediates fast inhibitory neurotransmission in the spinal cord, brainstem and retina. Loss of synaptic glycinergic transmission in vertebrates leads to a severe locomotion defect characterized by an exaggerated startle response accompanied by transient muscle rigidity in response to sudden acoustic or tactile stimuli. Several molecular components of the glycinergic synapse have been characterized as an outcome of genetic and physiological analyses of synaptogenesis in mammals. Recently, the glycinergic synapse has been studied using a forward genetic approach in zebrafish. This review aims to discuss molecular components of the glycinergic synapse, such as glycine receptor subunits, gephyrin, gephyrin-binding proteins and glycine transporters, as well as recent studies relevant to the genetic analysis of the glycinergic synapse in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping