ZFIN ID: ZDB-PUB-110701-6
The biological role of the glycinergic synapse in early zebrafish motility
Hirata, H., Takahashi, M., Yamada, K., and Ogino, K.
Date: 2011
Source: Neuroscience research   71(1): 1-11 (Journal)
Registered Authors: Hirata, Hiromi
Keywords: zebrafish, mutant, glycine, synapse, receptor, transporter
MeSH Terms:
  • Animals
  • Glycine/genetics
  • Glycine/physiology*
  • Motor Activity/genetics
  • Motor Activity/physiology*
  • Receptors, Glycine/genetics
  • Receptors, Glycine/physiology
  • Synapses/genetics
  • Synapses/physiology*
  • Zebrafish/genetics
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology*
PubMed: 21712054 Full text @ Neurosci. Res.
Glycine mediates fast inhibitory neurotransmission in the spinal cord, brainstem and retina. Loss of synaptic glycinergic transmission in vertebrates leads to a severe locomotion defect characterized by an exaggerated startle response accompanied by transient muscle rigidity in response to sudden acoustic or tactile stimuli. Several molecular components of the glycinergic synapse have been characterized as an outcome of genetic and physiological analyses of synaptogenesis in mammals. Recently, the glycinergic synapse has been studied using a forward genetic approach in zebrafish. This review aims to discuss molecular components of the glycinergic synapse, such as glycine receptor subunits, gephyrin, gephyrin-binding proteins and glycine transporters, as well as recent studies relevant to the genetic analysis of the glycinergic synapse in zebrafish.