ZFIN ID: ZDB-PUB-110629-45
Zebrafish as a model for normal and malignant hematopoiesis
Jing, L., and Zon, L.I.
Date: 2011
Source: Disease models & mechanisms   4(4): 433-438 (Journal)
Registered Authors: Jing, Lili, Zon, Leonard I.
Keywords: none
MeSH Terms:
  • Animals
  • Disease Models, Animal
  • Genetic Testing
  • Hematologic Diseases/pathology*
  • Hematologic Diseases/physiopathology*
  • Hematopoiesis/physiology*
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Zebrafish/genetics
  • Zebrafish/physiology*
PubMed: 21708900 Full text @ Dis. Model. Mech.
Zebrafish studies in the past two decades have made major contributions to our understanding of hematopoiesis and its associated disorders. The zebrafish has proven to be a powerful organism for studies in this area owing to its amenability to large-scale genetic and chemical screening. In addition, the externally fertilized and transparent embryos allow convenient genetic manipulation and in vivo imaging of normal and aberrant hematopoiesis. This review discusses available methods for studying hematopoiesis in zebrafish, summarizes key recent advances in this area, and highlights the current and potential contributions of zebrafish to the discovery and development of drugs to treat human blood disorders.