PUBLICATION
Chronic zebrafish PFOS exposure alters sex ratio and maternal related effects in F1 offspring
- Authors
- Wang, M., Chen, J., Lin, K., Chen, Y., Hu, W., Tanguay, R.L., Huang, C., and Dong, Q.
- ID
- ZDB-PUB-110628-18
- Date
- 2011
- Source
- Environmental toxicology and chemistry 30(9): 2073-80 (Journal)
- Registered Authors
- Tanguay, Robyn L.
- Keywords
- zebrafish embryo, chronic exposure, perfluorooctanesulfonic acid, sex ratio, locomotion
- MeSH Terms
-
- Alkanesulfonic Acids/toxicity*
- Animals
- Embryo, Nonmammalian/drug effects
- Female
- Fertility
- Fluorocarbons/toxicity*
- Larva
- Male
- Maternal Exposure
- Muscle Development/drug effects
- Neurons/drug effects
- Reproduction/drug effects*
- Sex Ratio
- Sperm Count
- Spermatozoa/drug effects
- Toxicity Tests, Chronic
- Water Pollutants, Chemical/toxicity*
- Zebrafish/embryology
- Zebrafish/growth & development
- PubMed
- 21671259 Full text @ Environ. Toxicol. Chem.
Citation
Wang, M., Chen, J., Lin, K., Chen, Y., Hu, W., Tanguay, R.L., Huang, C., and Dong, Q. (2011) Chronic zebrafish PFOS exposure alters sex ratio and maternal related effects in F1 offspring. Environmental toxicology and chemistry. 30(9):2073-80.
Abstract
Perfluorooctanesulfonic acid (PFOS) is an organic contaminant ubiquitous in the environment, wildlife and humans. Few studies have assessed its chronic toxicity on aquatic organisms. The present study defined the effects of long-term exposure to PFOS on zebrafish development and reproduction. Specifically, zebrafish at 8 h post-fertilization (hpf) were exposed to PFOS at 0, 5, 50, and 250 μg/L for 5 months. Growth suppression was observed in the 250 μg/L PFOS-treated group. The sex ratio was altered, with a significant female dominance in the high dose PFOS group. Male gonad development was also impaired in a dose-dependent manner by PFOS exposure. Although female fecundity was not impacted, the F1 embryos derived from high dose exposed females paired with males without PFOS exposure developed severe deformity at early development stages and resulted in 100% larval mortality at 7 dpf. Perfluorooctanesulfonic acid quantification in embryos indicated that decreased larval survival in F1 offspring was directly correlated to the PFOS body burden, and larval lethality was due to maternal transfer of PFOS to the eggs. Lower dose parental PFOS exposure, did not result in decreased F1 survival; however, the offspring displayed hyperactivity of basal swimming speed in a light-to-dark behavior assessment test. These findings demonstrate that chronic exposure to PFOS adversely impacts embryonic growth, reproduction and subsequent offspring development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping