PUBLICATION
The visual system of zebrafish and its use to model human ocular diseases
- Authors
- Gestri, G., Link, B.A., and Neuhauss, S.C.
- ID
- ZDB-PUB-110602-19
- Date
- 2012
- Source
- Developmental Neurobiology 72(3): 302-327 (Review)
- Registered Authors
- Gestri, Gaia, Link, Brian, Neuhauss, Stephan
- Keywords
- zebrafish, eye, anterior segment, retina, lens, photoreceptor, glaucoma, myopia, coloboma, holoprosencephaly
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Eye/growth & development*
- Eye/ultrastructure
- Eye Diseases/pathology
- Eye Diseases/physiopathology*
- Humans
- Morphogenesis/physiology
- Visual Pathways/growth & development*
- Visual Pathways/physiopathology
- Visual Pathways/ultrastructure
- Zebrafish
- PubMed
- 21595048 Full text @ Dev. Neurobiol.
Citation
Gestri, G., Link, B.A., and Neuhauss, S.C. (2012) The visual system of zebrafish and its use to model human ocular diseases. Developmental Neurobiology. 72(3):302-327.
Abstract
Free swimming zebrafish larvae depend mainly on their sense of vision to evade predation and to catch prey. Hence there is strong selective pressure on the fast maturation of visual function and indeed the visual system already supports a number of visually-driven behaviors in the newly hatched larvae. The ability to exploit the genetic and embryonic accessibility of the zebrafish in combination with a behavioral assessment of visual system function has made the zebrafish a popular model to study vision and its diseases. Here, we review the anatomy, physiology and development of the zebrafish eye as the basis to relate the contributions of the zebrafish to our understanding of human ocular diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping