PUBLICATION
Behavioral effects of titanium dioxide nanoparticles on larval zebrafish (Danio rerio)
- Authors
- Chen, T.H., Lin, C.Y., and Tseng, M.C.
- ID
- ZDB-PUB-110524-18
- Date
- 2011
- Source
- Marine pollution bulletin 63(5-12): 303-8 (Journal)
- Registered Authors
- Chen, Te-Hao
- Keywords
- titanium dioxide, nanoparticles, zebrafish, behavior
- MeSH Terms
-
- Animals
- Dose-Response Relationship, Drug
- Embryo, Nonmammalian/abnormalities
- Embryo, Nonmammalian/drug effects*
- Larva/drug effects
- Metal Nanoparticles/toxicity*
- Titanium/toxicity*
- Water Pollutants, Chemical/toxicity*
- Zebrafish
- PubMed
- 21565364 Full text @ Mar. Pollut. Bull.
Citation
Chen, T.H., Lin, C.Y., and Tseng, M.C. (2011) Behavioral effects of titanium dioxide nanoparticles on larval zebrafish (Danio rerio). Marine pollution bulletin. 63(5-12):303-8.
Abstract
In this study, zebrafish embryos were exposed to titanium dioxide nanoparticles (TiO2 NPs at 0.1, 0.5, 1, 5, 10 mg/L or control) from fertilization to free swimming stage. Hatchability, survival, and malformation rate were not affected by TiO2 NPs at these exposure levels. However, larval swimming parameters, including average and maximum velocity and activity level were significantly affected by TiO2 NPs. Co-exposure to either the glutathione precursor, N-acetylcysteine (NAC), or the glutathione synthesis inhibitor, buthionine sulfoximine (BSO), did not significantly alter the behavioral effects resulting from TiO2 NPs, suggesting that other factor(s) besides oxidative stress may contribute to the behavioral toxicity of TiO2 NPs. Our study also demonstrated that the behavioral endpoints were more sensitive than the others (e.g., hatchability and survival) to detect toxicity of TiO2 NPs on developing fish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping