PUBLICATION
Fishing pluripotency mechanisms in vivo
- Authors
- Sánchez-Sánchez, A.V., Camp, E., and Mullor, J.L.
- ID
- ZDB-PUB-110520-14
- Date
- 2011
- Source
- International journal of biological sciences 7(4): 410-7 (Review)
- Registered Authors
- Camp, Esther
- Keywords
- nanog, oct4, teleost fish, medaka, pluripotency
- MeSH Terms
-
- Animals
- Gonads/metabolism
- Homeodomain Proteins/metabolism
- Homeodomain Proteins/physiology
- Humans
- Mammals/metabolism
- Mice
- Octamer Transcription Factor-3/metabolism
- Octamer Transcription Factor-3/physiology
- Oryzias/embryology
- Oryzias/metabolism*
- Pluripotent Stem Cells/metabolism
- Pluripotent Stem Cells/physiology*
- Zebrafish/embryology
- Zebrafish/metabolism*
- PubMed
- 21547058 Full text @ Int. J. Biol. Sci.
Citation
Sánchez-Sánchez, A.V., Camp, E., and Mullor, J.L. (2011) Fishing pluripotency mechanisms in vivo. International journal of biological sciences. 7(4):410-7.
Abstract
To understand the molecular mechanisms that regulate the biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo in their natural environment. It is particularly important to study the roles and interactions of the different proteins involved in pluripotency and to use this knowledge for therapeutic purposes. The recent description of key pluripotency factors like Oct4 and Nanog in non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish and medaka, to the study of pluripotency in vivo. These animal models complement the mouse model and have provided new insights into the evolution of Oct4 and Nanog and their different functions during embryonic development. Furthermore, other pluripotency factors previously identified in teleost fish such as Klf4, STAT3, Sox2, telomerase and Tcf3 can now be studied in the context of a functional pluripotency network. The many experimental advantages of fish will fuel rapid analysis of the roles of pluripotency factors in fish embryonic development and the identification of new molecules and mechanisms governing pluripotency.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping