PUBLICATION

Tissue regeneration after injury in adult zebrafish: The regenerative potential of the caudal fin

Authors
Shao, J., Chen, D., Ye, Q., Cui, J., Li, Y., and Li, L..
ID
ZDB-PUB-110408-3
Date
2011
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   240(5): 1271-1277 (Journal)
Registered Authors
Li, Lei, Li, Yuhao
Keywords
zebrafish; regeneration potential; caudal fin, marker gene expression
MeSH Terms
  • Animal Fins/embryology*
  • Animal Fins/physiology*
  • Animals
  • Gene Expression Regulation, Developmental
  • Regeneration/physiology*
  • Zebrafish/embryology*
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed
21412938 Full text @ Dev. Dyn.
Abstract
The zebrafish has the potential to regenerate many of its tissues. In this study, we examined caudal fin regeneration in zebrafish that received repeated injuries (fin amputation) at different ages. In zebrafish that received repeated injuries, the potential for caudal fin regeneration, such as tissue growth and the expression of regeneration marker genes (msxb, fgf20a, bmp2b), did not decline in comparison to zebrafish that received only one amputation surgery. The process of initial fin regeneration (e.g., tissue outgrowth and the expression of regeneration marker genes at 7 days post-amputation) did not seem to correlate with age. However, slight differences in fin outgrowth were observed between young and old animals when examined in the late regeneration stages (e.g., 20 and 30 days post-amputation). Together, the data suggest that zebrafish has unlimited regenerative potential in the injured caudal fin. Developmental Dynamics, 2011.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping