PUBLICATION
The Zebrafish: A Powerful Platform for In Vivo, HTS Drug Discovery
- Authors
- Delvecchio, C., Tiefenbach, J., and Krause, H.M.
- ID
- ZDB-PUB-110214-33
- Date
- 2011
- Source
- Assay and drug development technologies 9(4): 354-61 (Review)
- Registered Authors
- Krause, Henry, Tiefenbach, Jens
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Drug Discovery/methods*
- Drug Evaluation, Preclinical
- High-Throughput Screening Assays/methods*
- Molecular Targeted Therapy*
- Zebrafish*
- PubMed
- 21309713 Full text @ Assay Drug Dev. Technol.
Citation
Delvecchio, C., Tiefenbach, J., and Krause, H.M. (2011) The Zebrafish: A Powerful Platform for In Vivo, HTS Drug Discovery. Assay and drug development technologies. 9(4):354-61.
Abstract
The zebrafish (Danio rerio) is an emerging vertebrate model for drug discovery that permits whole animal drug screens with excellent throughput, combined with ease of use and low cost. This review will begin with a discussion on the background, suitability, and advantages of this vertebrate model system and then, citing specific examples, will describe the utility of zebrafish at specific stages in the drug development pipeline. We will end with a synopsis of recent drug screens based on morphological disruptions, genetic disease models, fluorescent markers, behavioral changes, and specific targets. The numerous advantages of this whole animal approach provide new promise for the discovery of safe, specific, and powerful new drugs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping