ZFIN ID: ZDB-PUB-110131-34
Modeling Neurodegeneration in Zebrafish
Xi, Y., Noble, S., and Ekker, M.
Date: 2011
Source: Current neurology and neuroscience reports   11(3): 274-82 (Review)
Registered Authors: Ekker, Marc, Xi, Yanwei
Keywords: Zebrafish, Neurodegenerative diseases, Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, Dopaminergic neuron
MeSH Terms:
  • Alzheimer Disease/genetics
  • Animals
  • Disease Models, Animal*
  • Humans
  • Huntington Disease/genetics
  • Intracellular Signaling Peptides and Proteins/genetics
  • LDL-Receptor Related Proteins/genetics
  • Membrane Transport Proteins/genetics
  • Neurodegenerative Diseases/genetics*
  • Neurodegenerative Diseases/pathology*
  • Neurodegenerative Diseases/physiopathology*
  • Oncogene Proteins/genetics
  • Parkinson Disease/genetics
  • Protein Kinases/genetics
  • Protein-Serine-Threonine Kinases/genetics
  • Ubiquitin-Protein Ligases/genetics
  • Zebrafish/genetics*
  • tau Proteins/genetics
PubMed: 21271309 Full text @ Curr. Neurol. Neurosci. Rep.
The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson's, Huntington's, and Alzheimer's. These studies indicate that zebrafish genes and their human homologues have conserved functions with respect to the etiology of neurodegenerative diseases. The characteristics of the zebrafish and the experimental approaches to which it is amenable make this species a useful complement to other animal models for the study of pathologic mechanisms of neurodegenerative diseases and for the screening of compounds with therapeutic potential.