PUBLICATION
Establishment of a proneural field in the inner ear
- Authors
- Abello, G., and Alsina, B.
- ID
- ZDB-PUB-110119-3
- Date
- 2007
- Source
- The International journal of developmental biology 51(6-7): 483-493 (Review)
- Registered Authors
- Alsina, Berta
- Keywords
- bHLH, proneural gene, notch signaling, FGF signaling, SoxB1, neural induction
- MeSH Terms
-
- Animals
- Ear, Inner/cytology*
- Ear, Inner/embryology*
- Ear, Inner/metabolism
- Embryo, Nonmammalian/metabolism
- Embryonic Induction
- Fibroblast Growth Factors/genetics
- Fibroblast Growth Factors/metabolism
- Gene Expression Regulation, Developmental
- Hair Cells, Auditory/metabolism
- Labyrinth Supporting Cells/cytology
- Labyrinth Supporting Cells/metabolism
- Mechanotransduction, Cellular
- Models, Biological
- Neurons, Afferent/metabolism
- Receptors, Notch/metabolism
- Signal Transduction
- Transcription Factors/genetics
- Transcription Factors/metabolism
- PubMed
- 17891711 Full text @ Int. J. Dev. Biol.
Citation
Abello, G., and Alsina, B. (2007) Establishment of a proneural field in the inner ear. The International journal of developmental biology. 51(6-7):483-493.
Abstract
Hair-cells, supporting cells and sensory neurons are the main specialized cell-types responsible for mechanotransduction in the inner ear. They derive from precursors expressing proneural genes and recent data has underlined the importance of SoxB1 genes as upstream activators of proneural genes during cranial placode development. Here we review the steps of establishing a proneural field and propose several models for how early otic regionalization into a proneural territory is achieved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping