|ZFIN ID: ZDB-PUB-110119-3|
Establishment of a proneural field in the inner ear
Abello, G., and Alsina, B.
|Source:||The International journal of developmental biology 51(6-7): 483-493 (Review)|
|Registered Authors:||Alsina, Berta|
|Keywords:||bHLH, proneural gene, notch signaling, FGF signaling, SoxB1, neural induction|
|PubMed:||17891711 Full text @ Int. J. Dev. Biol.|
Abello, G., and Alsina, B. (2007) Establishment of a proneural field in the inner ear. The International journal of developmental biology. 51(6-7):483-493.
ABSTRACTHair-cells, supporting cells and sensory neurons are the main specialized cell-types responsible for mechanotransduction in the inner ear. They derive from precursors expressing proneural genes and recent data has underlined the importance of SoxB1 genes as upstream activators of proneural genes during cranial placode development. Here we review the steps of establishing a proneural field and propose several models for how early otic regionalization into a proneural territory is achieved.
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