ZFIN ID: ZDB-PUB-110119-3
Establishment of a proneural field in the inner ear
Abello, G., and Alsina, B.
Date: 2007
Source: The International journal of developmental biology   51(6-7): 483-493 (Review)
Registered Authors: Alsina, Berta
Keywords: bHLH, proneural gene, notch signaling, FGF signaling, SoxB1, neural induction
MeSH Terms:
  • Animals
  • Ear, Inner/cytology*
  • Ear, Inner/embryology*
  • Ear, Inner/metabolism
  • Embryo, Nonmammalian/metabolism
  • Embryonic Induction
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/metabolism
  • Gene Expression Regulation, Developmental
  • Hair Cells, Auditory/metabolism
  • Labyrinth Supporting Cells/cytology
  • Labyrinth Supporting Cells/metabolism
  • Mechanotransduction, Cellular
  • Models, Biological
  • Neurons, Afferent/metabolism
  • Receptors, Notch/metabolism
  • Signal Transduction
  • Transcription Factors/genetics
  • Transcription Factors/metabolism
PubMed: 17891711 Full text @ Int. J. Dev. Biol.
Hair-cells, supporting cells and sensory neurons are the main specialized cell-types responsible for mechanotransduction in the inner ear. They derive from precursors expressing proneural genes and recent data has underlined the importance of SoxB1 genes as upstream activators of proneural genes during cranial placode development. Here we review the steps of establishing a proneural field and propose several models for how early otic regionalization into a proneural territory is achieved.