ZFIN ID: ZDB-PUB-110103-29
Zebrafish: A Model System to Study Heritable Skin Diseases
Li, Q., Frank, M., Thisse, C.I., Thisse, B.V., and Uitto, J.
Date: 2011
Source: The Journal of investigative dermatology   131(3): 565-571 (Journal)
Registered Authors: Thisse, Bernard, Thisse, Christine
Keywords: none
MeSH Terms:
  • Animals
  • Cell Membrane/metabolism
  • Cell Membrane/ultrastructure
  • Epidermis/cytology
  • Epidermis/metabolism
  • Epidermis/ultrastructure
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Mice
  • Models, Animal*
  • Skin Diseases/genetics*
  • Skin Diseases/metabolism
  • Zebrafish*
PubMed: 21191402 Full text @ J. Invest. Dermatol.
Heritable skin diseases represent a broad spectrum of clinical manifestations due to mutations in <500 different genes. A number of model systems have been developed to advance our understanding of the pathomechanisms of genodermatoses. Zebrafish (Danio rerio), a freshwater vertebrate, has a well-characterized genome, the expression of which can be easily manipulated. The larvae develop rapidly, with all major organs having developed by 5-6 days post-fertilization, including the skin, consisting of the epidermis comprising two cell layers and separated from the dermal collagenous matrix by a basement membrane. This perspective highlights the morphological and ultrastructural features of zebrafish skin, in the context of cutaneous gene expression. These observations suggest that zebrafish provide a useful model system to study the molecular aspects of skin development, as well as the pathogenesis and treatment of select heritable skin diseases.