PUBLICATION
Zebrafish: A Model System to Study Heritable Skin Diseases
- Authors
- Li, Q., Frank, M., Thisse, C.I., Thisse, B.V., and Uitto, J.
- ID
- ZDB-PUB-110103-29
- Date
- 2011
- Source
- The Journal of investigative dermatology 131(3): 565-571 (Journal)
- Registered Authors
- Thisse, Bernard, Thisse, Christine
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Membrane/metabolism
- Cell Membrane/ultrastructure
- Epidermis/cytology
- Epidermis/metabolism
- Epidermis/ultrastructure
- Gene Expression Profiling
- Gene Expression Regulation
- Mice
- Models, Animal*
- Skin Diseases/genetics*
- Skin Diseases/metabolism
- Zebrafish*
- PubMed
- 21191402 Full text @ J. Invest. Dermatol.
Citation
Li, Q., Frank, M., Thisse, C.I., Thisse, B.V., and Uitto, J. (2011) Zebrafish: A Model System to Study Heritable Skin Diseases. The Journal of investigative dermatology. 131(3):565-571.
Abstract
Heritable skin diseases represent a broad spectrum of clinical manifestations due to mutations in <500 different genes. A number of model systems have been developed to advance our understanding of the pathomechanisms of genodermatoses. Zebrafish (Danio rerio), a freshwater vertebrate, has a well-characterized genome, the expression of which can be easily manipulated. The larvae develop rapidly, with all major organs having developed by 5-6 days post-fertilization, including the skin, consisting of the epidermis comprising two cell layers and separated from the dermal collagenous matrix by a basement membrane. This perspective highlights the morphological and ultrastructural features of zebrafish skin, in the context of cutaneous gene expression. These observations suggest that zebrafish provide a useful model system to study the molecular aspects of skin development, as well as the pathogenesis and treatment of select heritable skin diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping