PUBLICATION
Bipolar cells in the zebrafish retina
- Authors
- Connaughton, V.P.
- ID
- ZDB-PUB-101122-14
- Date
- 2011
- Source
- Visual neuroscience 28(1): 77-93 (Review)
- Registered Authors
- Connaughton, Victoria P.
- Keywords
- Second-order neurons, Electrophysiology, Development, Danio rerio
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Electrophysiological Phenomena/physiology
- Gene Expression
- Ion Channel Gating/physiology
- Mutation/physiology
- Receptors, Dopamine/physiology
- Receptors, GABA/physiology
- Receptors, Glutamate/physiology
- Receptors, Glycine/physiology
- Retina/growth & development
- Retina/physiology*
- Retinal Bipolar Cells/physiology*
- Zebrafish/physiology*
- PubMed
- 21080977 Full text @ Vis. Neurosci.
Citation
Connaughton, V.P. (2011) Bipolar cells in the zebrafish retina. Visual neuroscience. 28(1):77-93.
Abstract
Zebrafish are an existing model for genetic and developmental studies due to their rapid external development and transparent embryos, which allow easy manipulation and observation of early developmental stages. The application of the zebrafish model to vision research has allowed for examination of retinal development and the characteristics of different retinal cell types, including bipolar cells. In particular, bipolar cell development, including differentiation, maturation, and gene expression, has been documented, as has physiological properties, such as voltage- and ligand-gated currents, and neurotransmitter receptor and ion channel expression. Mutant strains and transgenic lines have been used to document how bipolar cell connections and/or development may be altered, and toxicological studies examining how environmental factors may impact bipolar cell activity have been performed. The purpose of this paper was to review the existing literature on zebrafish bipolar cells, to provide a comprehensive overview of current information pertaining to this retinal cell type.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping