PUBLICATION
bmp2b and bmp4 are dispensable for zebrafish tooth development
- Authors
- Wise, S.B., and Stock, D.W.
- ID
- ZDB-PUB-101108-11
- Date
- 2010
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 239(10): 2534-2546 (Journal)
- Registered Authors
- Stock, David W.
- Keywords
- bone morphogenetic protein, zebrafish, dentition, swr
- MeSH Terms
-
- Animals
- Zebrafish/embryology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Tooth/embryology*
- Tooth/metabolism*
- Gastrulation/genetics
- Gastrulation/physiology
- Bone Morphogenetic Protein 2/genetics
- Bone Morphogenetic Protein 2/metabolism*
- Odontogenesis/genetics
- Odontogenesis/physiology
- Gene Expression Regulation, Developmental
- Alleles
- Homozygote
- Animals, Genetically Modified
- Bone Morphogenetic Protein 4/genetics
- Bone Morphogenetic Protein 4/metabolism*
- PubMed
- 21038444 Full text @ Dev. Dyn.
Citation
Wise, S.B., and Stock, D.W. (2010) bmp2b and bmp4 are dispensable for zebrafish tooth development. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2534-2546.
Abstract
Bone morphogenetic protein (Bmp) signaling has been shown to play important roles in tooth development at virtually all stages from initiation to hard tissue formation. The specific ligands involved in these processes have not been directly tested by loss-of-function experiments, however. We used morpholino antisense oligonucleotides and mutant analysis in the zebrafish to reduce or eliminate the function of bmp2b and bmp4, two ligands known to be expressed in zebrafish teeth and whose mammalian orthologs are thought to play important roles in tooth development. Surprisingly, we found that elimination of function of these two genes singly and in combination did not prevent the formation of mature, attached teeth. The mostly likely explanation for this result is functional redundancy with other Bmp ligands, which may differ between the zebrafish and the mouse.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping