ZFIN ID: ZDB-PUB-101108-11
bmp2b and bmp4 are dispensable for zebrafish tooth development
Wise, S.B., and Stock, D.W.
Date: 2010
Source: Developmental dynamics : an official publication of the American Association of Anatomists   239(10): 2534-2546 (Journal)
Registered Authors: Stock, David W.
Keywords: bone morphogenetic protein, zebrafish, dentition, swr
MeSH Terms:
  • Alleles
  • Animals
  • Animals, Genetically Modified
  • Bone Morphogenetic Protein 2/genetics
  • Bone Morphogenetic Protein 2/metabolism*
  • Bone Morphogenetic Protein 4/genetics
  • Bone Morphogenetic Protein 4/metabolism*
  • Gastrulation/genetics
  • Gastrulation/physiology
  • Gene Expression Regulation, Developmental
  • Homozygote
  • Odontogenesis/genetics
  • Odontogenesis/physiology
  • Tooth/embryology*
  • Tooth/metabolism*
  • Zebrafish/embryology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 21038444 Full text @ Dev. Dyn.
Bone morphogenetic protein (Bmp) signaling has been shown to play important roles in tooth development at virtually all stages from initiation to hard tissue formation. The specific ligands involved in these processes have not been directly tested by loss-of-function experiments, however. We used morpholino antisense oligonucleotides and mutant analysis in the zebrafish to reduce or eliminate the function of bmp2b and bmp4, two ligands known to be expressed in zebrafish teeth and whose mammalian orthologs are thought to play important roles in tooth development. Surprisingly, we found that elimination of function of these two genes singly and in combination did not prevent the formation of mature, attached teeth. The mostly likely explanation for this result is functional redundancy with other Bmp ligands, which may differ between the zebrafish and the mouse.