ZFIN ID: ZDB-PUB-101027-23
The effects of hyperglycemia on adrenal cortex function and steroidogenesis in the zebrafish
Powers, J.W., Mazilu, J.K., Lin, S., and McCabe, E.R.
Date: 2010
Source: Molecular genetics and metabolism   101(4): 421-422 (Journal)
Registered Authors: Lin, Shuo
Keywords: Diabetes mellitus, Hyperglycemia, Cortisol, Zebrafish
MeSH Terms:
  • Adrenal Cortex/physiopathology*
  • Animals
  • Disease Models, Animal
  • Glucose/metabolism
  • Hydrocortisone/metabolism
  • Hyperglycemia/metabolism*
  • Hyperglycemia/physiopathology*
  • Pituitary-Adrenal System/physiopathology
  • Steroids/biosynthesis*
  • Zebrafish
PubMed: 20961780 Full text @ Mol. Genet. Metab.
Since the 1950s, scientists have attempted to characterize the relationship between diabetes mellitus (DM) and the hypothalamic-pituitary-adrenal (HPA) axis. Similar complications are seen in patients with diabetes and Cushing's syndrome, leading some to suggest that an underlying abnormality in the HPA axis may be responsible among those with DM. By inducing hyperglycemia in a zebrafish animal model, we show a direct correlation between glucose and cortisol levels.