ZFIN ID: ZDB-PUB-101004-34
Zebrafish: A tool for chemical screens
Tsang, M.
Date: 2010
Source: Birth defects research. Part C, Embryo today : reviews   90(3): 185-192 (Review)
Registered Authors: Tsang, Michael
Keywords: zebrafish, chemical screens
MeSH Terms:
  • Animals
  • Animals, Genetically Modified/embryology
  • Drug Discovery
  • Embryo, Nonmammalian/drug effects
  • Models, Animal*
  • Signal Transduction
  • Zebrafish*
PubMed: 20860058 Full text @ Birth Defects Res. C Embryo Today
ABSTRACT
The zebrafish has proven to be an invaluable vertebrate animal model for developmental biology. Recent technological advances have added an arsenal of tools to expand its use into the realm of drug discovery. This includes methodology to generate transgenic reporter lines that allow for the direct visualization of fluorescent markers in live embryos. With the addition of automated imaging and analysis of embryos treated with small molecules, these innovations have expanded its utility into high throughput chemical screens. This review will highlight some of these advances that have propelled zebrafish as a tool for drug discovery.
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