PUBLICATION
Anti-angiogenic effects of the fruit of Alpinia oxyphylla
- Authors
- He, Z.H., Ge, W., Yue, G.G., Lau, C.B., He, M.F., and But, P.P.
- ID
- ZDB-PUB-100826-1
- Date
- 2010
- Source
- Journal of ethnopharmacology 132(2): 443-449 (Journal)
- Registered Authors
- Ge, Wei
- Keywords
- Alpinia oxyphylla, Zingiberaceae, Anti-angiogenesis, Zebrafish, HUVEC
- MeSH Terms
-
- Alkaline Phosphatase/metabolism
- Alpinia*
- Angiogenesis Inhibitors/pharmacology*
- Animals
- Cell Line
- Cell Proliferation/drug effects
- Embryo, Nonmammalian
- Endothelial Cells/drug effects
- Endothelial Cells/metabolism
- Fruit
- Hep G2 Cells
- Humans
- Neovascularization, Pathologic/drug therapy*
- Neovascularization, Physiologic/drug effects*
- Phytotherapy*
- Plant Extracts/pharmacology*
- Zebrafish
- PubMed
- 20723592 Full text @ J. Ethnopharmacol.
Citation
He, Z.H., Ge, W., Yue, G.G., Lau, C.B., He, M.F., and But, P.P. (2010) Anti-angiogenic effects of the fruit of Alpinia oxyphylla. Journal of ethnopharmacology. 132(2):443-449.
Abstract
AIM OF STUDY: The fruit of Alpinia oxyphylla, an herb commonly used in East Asian medicine, is variously used for the treatment of cancer and inflammatory conditions, which may possibly be mediated through anti-angiogenesis. This study aims to check for anti-angiogenic functions in the herb.
MATERIALS AND METHODS: The 95% ethanol extract and four subsequent fractions (n-hexane, ethyl acetate, n-butanol and aqueous fractions) of the fruit of A. oxyphylla were tested on zebrafish model by quantitative endogenous alkaline phosphatase assay; then the active fractions were further tested on wild type and Tg(fli1a:EGFP)y1 zebrafish embryos and human umbilical vein endothelial cells and tumor cell lines for the anti-angiogenic effects.
RESULTS: The n-hexane and ethyl acetate fractions showed anti-angiogenic potentials in both in vivo and in vitro models.
CONCLUSIONS: The use of A. oxyphylla for cancer and inflammation diseases may be partly due to its effects against vessel formation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping