PUBLICATION
Regulation of facial morphogenesis by endothelin signaling: Insights from mice and fish
- Authors
- Clouthier, D.E., Garcia, E., and Schilling, T.F.
- ID
- ZDB-PUB-100806-21
- Date
- 2010
- Source
- American journal of medical genetics 152A(12): 2962-2973 (Review)
- Registered Authors
- Schilling, Tom
- Keywords
- endothelin, craniofacial development, neural crest cell, endothelin antagonist, zebrafish, morpholino, knockout mice, transgenic mice, Dlx
- MeSH Terms
-
- Animals
- Body Patterning/genetics
- Branchial Region/metabolism
- Endothelin-1/genetics
- Endothelin-1/metabolism
- Endothelins/genetics
- Endothelins/metabolism*
- Face/embryology*
- Fishes/genetics*
- Fishes/metabolism
- Gene Expression Regulation, Developmental
- Genes, Homeobox/genetics
- Jaw/metabolism
- Mandible/metabolism
- Mice
- Mice, Knockout
- Mice, Mutant Strains
- Models, Biological
- Morphogenesis/genetics
- Neural Crest/metabolism
- Receptor, Endothelin A/genetics
- Receptor, Endothelin A/metabolism
- Signal Transduction/genetics
- Signal Transduction/physiology*
- Zebrafish/genetics
- Zebrafish/metabolism
- PubMed
- 20684004 Full text @ Am. J. Med. Genet.
Citation
Clouthier, D.E., Garcia, E., and Schilling, T.F. (2010) Regulation of facial morphogenesis by endothelin signaling: Insights from mice and fish. American journal of medical genetics. 152A(12):2962-2973.
Abstract
Craniofacial morphogenesis is accomplished through a complex set of developmental events, most of which are initiated in neural crest cells within the pharyngeal arches. Local patterning cues from the surrounding environment induce gene expression within neural crest cells, leading to formation of a diverse set of skeletal elements. Endothelin-1 (Edn1) is one of the primary signals that establishes the identity of neural crest cells within the mandibular portion of the first pharyngeal arch. Signaling through its cognate receptor, the endothelin-A receptor, is critical for patterning the ventral/distal portion of the arch (lower jaw) and also participates with Hox genes in patterning more posterior arches. Edn1/Ednra signaling is highly conserved between mouse and zebrafish, and genetic analyses in these two species have provided complementary insights into the patterning cues responsible for establishing the craniofacial complex as well as the genetic basis of facial birth defect syndromes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping