PUBLICATION
Zebrafish Models of p53 Functions
- Authors
- Storer, N.Y., and Zon, L.I.
- ID
- ZDB-PUB-100806-14
- Date
- 2010
- Source
- Cold Spring Harbor perspectives in biology 2(8): a001123 (Review)
- Registered Authors
- Storer, Narie, Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Apoptosis
- Cell Cycle
- DNA-Binding Proteins/metabolism
- Gene Expression Regulation*
- Gene Expression Regulation, Neoplastic*
- Genes, p53*
- Humans
- Models, Animal
- Models, Genetic
- Molecular Biology/methods
- Nuclear Proteins/metabolism
- Phosphoproteins
- Ribosomal Proteins/metabolism
- Trans-Activators
- Tumor Suppressor Protein p53/metabolism*
- Tumor Suppressor Proteins/metabolism
- Zebrafish
- Zebrafish Proteins
- PubMed
- 20679337 Full text @ Cold Spring Harb. Perspect. Biol.
Citation
Storer, N.Y., and Zon, L.I. (2010) Zebrafish Models of p53 Functions. Cold Spring Harbor perspectives in biology. 2(8):a001123.
Abstract
Zebrafish models have significantly contributed to our understanding of vertebrate development and, more recently, human disease. The growing number of genetic tools available in zebrafish research has resulted in the identification of many genes involved in developmental and disease processes. In particular, studies in the zebrafish have clarified roles of the p53 tumor suppressor in the formation of specific tumor types, as well as roles of p53 family members during embryonic development. The zebrafish has also been instrumental in identifying novel mechanisms of p53 regulation and highlighting the importance of these mechanisms in vivo. This article will summarize how zebrafish models have been used to reveal numerous, important aspects of p53 function.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping