PUBLICATION

Progressive neurogenesis defines lateralis somatotopy

Authors
Pujol-Martí, J., Baudoin, J.P., Faucherre, A., Kawakami, K., and Lopez-Schier, H.
ID
ZDB-PUB-100621-19
Date
2010
Source
Developmental dynamics : an official publication of the American Association of Anatomists   239(7): 1919-1930 (Journal)
Registered Authors
Faucherre, Adele, Kawakami, Koichi, Lopez-Schier, Hernan, Marti, Jesus Pujol
Keywords
somatotopy, lateral line, Gal4, sensory neurons, zebrafish
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Ganglia, Sensory/cytology
  • Ganglia, Sensory/metabolism
  • Neurogenesis/genetics
  • Neurogenesis/physiology*
  • Sensory Receptor Cells/cytology
  • Sensory Receptor Cells/metabolism
  • Zebrafish/embryology*
  • Zebrafish/genetics
PubMed
20549716 Full text @ Dev. Dyn.
Abstract
Fishes and amphibians localize hydromechanical variations along their bodies using the lateral-line sensory system. This is possible because the spatial distribution of neuromasts is represented in the hindbrain by a somatotopic organization of the lateralis afferent neurons' central projections. The mechanisms that establish lateralis somatotopy are not known. Using BAPTI and neuronal tracing in the zebrafish, we demonstrate growth anisotropy of the posterior lateralis ganglion. We characterized a new transgenic line for in vivo imaging to show that although peripheral growth-cone structure adumbrates somatotopy, the order of neurogenesis represents a more accurate predictor of the position of a neuron's central axon along the somatotopic axis in the hindbrain. We conclude that progressive neurogenesis defines lateralis somatotopy.
Genes / Markers
Figures
Figure Gallery
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes