PUBLICATION

Some principles of organization of spinal neurons underlying locomotion in zebrafish and their implications

Authors
Fetcho, J.R., and McLean, D.L.
ID
ZDB-PUB-100614-33
Date
2010
Source
Annals of the New York Academy of Sciences   1198: 94-104 (Review)
Registered Authors
Fetcho, Joseph R.
Keywords
motoneurons, spinal interneurons, transcription factors, locomotion, motor pattern
MeSH Terms
  • Animals
  • Cell Differentiation
  • Chickens
  • Electrophysiology
  • Interneurons/cytology
  • Interneurons/physiology
  • Locomotion/physiology*
  • Mice
  • Motor Activity/physiology
  • Motor Neurons/cytology
  • Motor Neurons/physiology
  • Nerve Net/physiology
  • Neurons/physiology*
  • Ranidae
  • Species Specificity
  • Spinal Cord/cytology
  • Spinal Cord/physiology*
  • Swimming/physiology
  • Synaptic Transmission/physiology
  • Zebrafish/physiology*
PubMed
20536924 Full text @ Ann N Y Acad Sci
Abstract
Recent studies of the spinal motor system of zebrafish, along with work in other species, are leading to some principles that appear to underlie the organization and recruitment of motor networks in cord: (1) broad neuronal classes defined by a set of transcription factors, key morphological features, and transmitter phenotypes arise in an orderly way from different dorso-ventral zones in spinal cord; (2) motor behaviors and both motoneurons and interneurons differentiate in order from gross, often faster, movements and the neurons driving them to progressively slower movements and their underlying neurons; (3) recruitment order of motoneurons and interneurons is based upon time of differentiation; (4) different locomotor speeds involve some shifts in the set of active interneurons. Here we review these principles and some of their implications for other parts of the brain, other vertebrates, and limbed locomotion.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping