ZFIN ID: ZDB-PUB-100511-21
Fly fishing for collective cell migration
Lopez-Schier, H.
Date: 2010
Source: Current opinion in genetics & development   20(4): 428-432 (Review)
Registered Authors: Lopez-Schier, Hernan
Keywords: none
MeSH Terms:
  • Animals
  • Cell Movement/genetics*
  • Cell Movement/physiology
  • Drosophila/cytology*
  • Drosophila/embryology
  • Drosophila/genetics
  • Drosophila Proteins/genetics
  • Drosophila Proteins/physiology
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/metabolism
  • Organogenesis/genetics
  • Signal Transduction
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology
PubMed: 20452199 Full text @ Curr. Opin. Genet. Dev.
The collective migration of cells is essential for organogenesis. It requires the establishment of spatial information within the cellular group and a mechanism that controls the onset of cell movement and migratory arrest. In this review I will use two examples of collective cell migration, from Drosophila and the zebrafish, to discuss how genetic analyses have helped to unravel some basic aspects of collective cell migration. Following, I will suggest some general experimental approaches to further advance our understanding of the mechanisms that control the migration of cellular collectives.