PUBLICATION
Characterisation of the zebrafish cerebellar efferent system
- Authors
- Babaryka, A.N.
- ID
- ZDB-PUB-100323-25
- Date
- 2009
- Source
- Ph.D. Thesis : (Thesis)
- Registered Authors
- Babaryka, Andreas
- Keywords
- cerebellum, eurydendroid cells, cell tracing, fate mapping, bioimaging
- MeSH Terms
- none
- PubMed
- none
Citation
Babaryka, A.N. (2009) Characterisation of the zebrafish cerebellar efferent system. Ph.D. Thesis. .
Abstract
The efferent system of the cerebellum is formed by the neurons of the deep cerebellar nuclei. Using morphology and expression analysis together with axon tracing I have identified and characterised this cell population, the Eurydendroid cells (ECs), in the zebrafish. With the help of transgenic lines expressing fluorescent proteins and in vivo time lapse analysis I have revealed the developmental period, their differentiation behaviour and their integration into the layered cerebellar cortex. Finally nmyc expression and its regulation were identified as a potential key factor in EC proliferation or specification. These results significantly expand our knowledge of cerebellar development in teleosts and their use as informative disease models.
Errata / Notes
Dissertation, Munchen, Techn. Univ.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping