PUBLICATION
Models of congenital deafness: Mouse and zebrafish
- Authors
- Whitfield, T.T., Mburu, P., Hardisty-Hughes, R.E., and Brown, S.D.M.
- ID
- ZDB-PUB-100323-1
- Date
- 2005
- Source
- Drug discovery today 2(2): 85-92 (Review)
- Registered Authors
- Whitfield, Tanya T.
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none Full text @ Drug Discov. Today
Citation
Whitfield, T.T., Mburu, P., Hardisty-Hughes, R.E., and Brown, S.D.M. (2005) Models of congenital deafness: Mouse and zebrafish. Drug discovery today. 2(2):85-92.
Abstract
Much of our understanding of the molecular mechanisms underlying hearing and deafness has come through the study of vertebrate model organisms. We review here the advantages and disadvantages of the mouse and the zebrafish as genetic model systems for hearing research. Despite anatomical differences, many of the key molecules required for hair cell development and function are highly conserved between the two species and both provide complementary approaches for the development of drugs to treat diseases of the ear.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping