PUBLICATION
Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss
- Authors
- Ou, H.C., Santos, F., Raible, D.W., Simon, J.A., and Rubel, E.W.
- ID
- ZDB-PUB-100126-15
- Date
- 2010
- Source
- Drug discovery today 15(7-8): 265-271 (Review)
- Registered Authors
- Raible, David
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Line
- Disease Models, Animal
- Drug Evaluation, Preclinical/methods*
- Drug-Related Side Effects and Adverse Reactions*
- Hair Cells, Auditory/drug effects
- Hair Cells, Auditory/physiology
- Hearing Loss/chemically induced*
- Hearing Loss/drug therapy*
- Humans
- Lateral Line System/physiology*
- Protective Agents/pharmacology
- Zebrafish/physiology*
- PubMed
- 20096805 Full text @ Drug Discov. Today
Citation
Ou, H.C., Santos, F., Raible, D.W., Simon, J.A., and Rubel, E.W. (2010) Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss. Drug discovery today. 15(7-8):265-271.
Abstract
Several animal models have been used for the study of mechanosensory hair cells and hearing loss. Because of the difficulty of tissue acquisition and large animal size, these traditional models are impractical for high-throughput screening. The zebrafish has emerged as a powerful animal model for screening drugs that cause or prevent hair cell death. The unique characteristics of the zebrafish enable rapid in vivo imaging of hair cells and hair cell death. We have used this model to screen for and identify multiple drugs that protect hair cells from aminoglycoside-induced death. Identification of multiple drugs and drug-like compounds that inhibit multiple hair cell death pathways might enable the development of protective cocktails to achieve complete hair cell protection.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping