|ZFIN ID: ZDB-PUB-091204-3|
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
Grabher, C., von Boehmer, H., and Look, A.T.
|Source:||Nature reviews. Cancer 6(5): 347-359 (Review)|
|Registered Authors:||Grabher, Clemens, Look, A. Thomas|
|PubMed:||16612405 Full text @ Nat. Rev. Cancer|
Grabher, C., von Boehmer, H., and Look, A.T. (2006) Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nature reviews. Cancer. 6(5):347-359.
ABSTRACTThe chromosomal translocation t(7;9) in human T-cell acute lymphoblastic leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch 1 (TAN1) under the control of the T-cell receptor-beta (TCRB) locus. Although TAN1 efficiently induces T-ALL in mouse models, t(7;9) is present in less than 1% of human T-ALL cases. The recent discovery of novel activating mutations in NOTCH1 in more than 50% of human T-ALL samples has made it clear that Notch 1 is far more important in human T-ALL pathogenesis than previously suspected.
ADDITIONAL INFORMATION No data available