PUBLICATION
Molecular Signaling Networks That Choreograph Epimorphic Fin Regeneration in Zebrafish - A Mini-Review
- Authors
- Tal, T.L., Franzosa, J.A., and Tanguay, R.L.
- ID
- ZDB-PUB-091120-72
- Date
- 2010
- Source
- Gerontology 56(2): 231-240 (Review)
- Registered Authors
- Tanguay, Robyn L.
- Keywords
- none
- MeSH Terms
-
- Animal Structures/physiology
- Animals
- Fibroblast Growth Factors/physiology
- Hedgehog Proteins/physiology
- Mesenchymal Stem Cells/physiology
- Models, Biological
- Multipotent Stem Cells/physiology
- RNA, Untranslated/genetics
- Regeneration/genetics
- Regeneration/physiology*
- Signal Transduction/physiology
- Tretinoin/physiology
- Wnt Proteins/physiology
- Wound Healing/physiology
- Zebrafish/genetics
- Zebrafish/physiology*
- Zebrafish Proteins/physiology
- beta Catenin/physiology
- PubMed
- 19923791 Full text @ Gerontology
Citation
Tal, T.L., Franzosa, J.A., and Tanguay, R.L. (2010) Molecular Signaling Networks That Choreograph Epimorphic Fin Regeneration in Zebrafish - A Mini-Review. Gerontology. 56(2):231-240.
Abstract
This short review provides a current synopsis of caudal fin regeneration in zebrafish with an emphasis on the molecular signaling networks that dictate epimorphic regeneration. At the outset, the fundamentals of caudal fin architecture and the stages of epimorphic regeneration are described. This is followed by a detailed look at the main networks implicated in fin regeneration, namely the Wnt, fibroblast growth factor, activin-betaA, retinoic acid and hedgehog signaling pathways. Throughout this mini-review, these molecular networks are examined through the lens of wound healing, blastema formation or regenerative outgrowth, three of the main stages of epimorphic regeneration. Next, the emerging role of noncoding RNAs as regulators of regeneration and mechanisms of regenerative termination are discussed. Finally, the implications for future research and the broader field of regenerative medicine are examined.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping