|ZFIN ID: ZDB-PUB-091120-29|
Vascular morphogenesis in the zebrafish embryo
Ellertsdóttir, E., Lenard, A., Blum, Y., Krudewig, A., Herwig, L., Affolter, M., and Belting, H.G.
|Source:||Developmental Biology 341(1): 56-65 (Review)|
|Registered Authors:||Affolter, Markus|
|Keywords:||Angiogenesis, Vasculogenesis, Branching morphogenesis, Cell migration, Lumen formation, Development, Zebrafish|
|PubMed:||19895803 Full text @ Dev. Biol.|
Ellertsdóttir, E., Lenard, A., Blum, Y., Krudewig, A., Herwig, L., Affolter, M., and Belting, H.G. (2010) Vascular morphogenesis in the zebrafish embryo. Developmental Biology. 341(1):56-65.
ABSTRACTDuring embryonic development, the vertebrate vasculature is undergoing vast growth and remodeling. Blood vessels can be formed by a wide spectrum of different morphogenetic mechanisms, such as budding, cord hollowing, cell hollowing, cell wrapping and intussusception. Here, we describe the vascular morphogenesis that occurs in the early zebrafish embryo. We discuss the diversity of morphogenetic mechanisms that contribute to vessel assembly, angiogenic sprouting and tube formation in different blood vessels and how some of these complex cell behaviors are regulated by molecular pathways.