ZFIN ID: ZDB-PUB-091120-29
Vascular morphogenesis in the zebrafish embryo
Ellertsdóttir, E., Lenard, A., Blum, Y., Krudewig, A., Herwig, L., Affolter, M., and Belting, H.G.
Date: 2010
Source: Developmental Biology   341(1): 56-65 (Review)
Registered Authors: Affolter, Markus
Keywords: Angiogenesis, Vasculogenesis, Branching morphogenesis, Cell migration, Lumen formation, Development, Zebrafish
MeSH Terms:
  • Animals
  • Blood Vessels/embryology*
  • Embryo, Nonmammalian/metabolism
  • Morphogenesis*
  • Zebrafish/embryology*
PubMed: 19895803 Full text @ Dev. Biol.
During embryonic development, the vertebrate vasculature is undergoing vast growth and remodeling. Blood vessels can be formed by a wide spectrum of different morphogenetic mechanisms, such as budding, cord hollowing, cell hollowing, cell wrapping and intussusception. Here, we describe the vascular morphogenesis that occurs in the early zebrafish embryo. We discuss the diversity of morphogenetic mechanisms that contribute to vessel assembly, angiogenic sprouting and tube formation in different blood vessels and how some of these complex cell behaviors are regulated by molecular pathways.