PUBLICATION
Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafish
- Authors
- Brown, A.M., Fisher, S., and Iovine, M.K.
- ID
- ZDB-PUB-091023-63
- Date
- 2009
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 238(11): 2922-2928 (Journal)
- Registered Authors
- Fisher, Shannon, Iovine, M. Kathryn
- Keywords
- bone growth, osteoblast maturation, fin regeneration, zebrafish, cx43
- MeSH Terms
-
- Animals
- Bone Regeneration*
- Cell Differentiation/physiology*
- Osteoblasts/cytology
- Osteoblasts/physiology*
- Osteogenesis/physiology*
- Osteopontin/metabolism
- Transcription Factors/metabolism
- Zebrafish/physiology*
- Zebrafish Proteins/metabolism
- PubMed
- 19842180 Full text @ Dev. Dyn.
Citation
Brown, A.M., Fisher, S., and Iovine, M.K. (2009) Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(11):2922-2928.
Abstract
During fin regeneration, osteoblasts must continually differentiate for outgrowth of the bony fin rays. Bone maturity increases in a distal-proximal manner, and osteoblast maturation can be detected similarly when following gene expression. We find that early markers for osteoblast differentiation are expressed in a discrete domain at the distal end of the fin, just proximal to the adjacent germinal compartment of dividing cells. Matrix genes, required at later stages developmentally, are expressed in a population of cells proximally to the early genes. A marker for mature osteoblasts is expressed in cells further proximal. These domains of gene expression are partially overlapping, perhaps revealing additional levels of osteoblast maturity. We suggest a model for growth where new cells are continually added to the distal-most osteoblast compartment, while osteoblasts in more proximal locations differentiate, thus translating developmental time to location on the proximal-distal axis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping