PUBLICATION
Effects of alpha particles on zebrafish embryos
- Authors
- Yum, E.H., Li, V.W., Choi, V.W., Cheng, S.H., and Yu, K.N.
- ID
- ZDB-PUB-091023-57
- Date
- 2010
- Source
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 68(4-5): 714-717 (Journal)
- Registered Authors
- Cheng, Shuk Han
- Keywords
- Radiation hormesis, Hormetic effect, Alpha particles, Zebrafish embryos
- MeSH Terms
-
- Alpha Particles
- Animals
- Apoptosis/radiation effects*
- Dose-Response Relationship, Radiation
- Embryo, Nonmammalian/cytology
- Embryo, Nonmammalian/embryology*
- Embryo, Nonmammalian/radiation effects*
- Embryonic Stem Cells/cytology*
- Embryonic Stem Cells/radiation effects*
- Radiation Dosage
- Zebrafish/embryology*
- PubMed
- 19837598 Full text @ Appl. Radiat. Isot.
Citation
Yum, E.H., Li, V.W., Choi, V.W., Cheng, S.H., and Yu, K.N. (2010) Effects of alpha particles on zebrafish embryos. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 68(4-5):714-717.
Abstract
Dechorionated zebrafish embryos were irradiated at 1.5h post fertilization (hpf) to low-doses of alpha particles, viz., 1.4, 2.8, 5.6, 11.2mGy (determined using Monte Carlo simulations). At 24hpf, these embryos were then examined for apoptotic cells through acridine orange staining. The mean number of apoptotic cells was found to decrease significantly from controls to 1.4-mGy irradiation, and then to increase almost linearly to 2.8, 5.6 and 11.2-mGy irradiation. This trend is a typical characteristic of a hormetic effect.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping