PUBLICATION
Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation
- Authors
- Larsson, T.A., Tay, B.H., Sundström, G., Fredriksson, R., Brenner, S., Larhammar, D., and Venkatesh, B.
- ID
- ZDB-PUB-091016-2
- Date
- 2009
- Source
- Genomics 93(3): 254-260 (Journal)
- Registered Authors
- Fredriksson, Robert, Larhammar, Dan, Larsson, Tomas A., Sundström, Görel, Venkatesh, Byrappa
- Keywords
- Evolution, Genome duplication, NPY, Elephant shark
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Chromosomes/genetics
- Databases, Genetic
- Gene Duplication*
- Gene Expression Regulation
- Molecular Sequence Data
- Neuropeptide Y/chemistry
- Neuropeptide Y/genetics*
- Phylogeny*
- Receptors, Neuropeptide Y/classification
- Receptors, Neuropeptide Y/genetics*
- Sequence Alignment
- Sharks/classification
- Sharks/genetics*
- Sharks/metabolism
- PubMed
- 18977429 Full text @ Genomics
Citation
Larsson, T.A., Tay, B.H., Sundström, G., Fredriksson, R., Brenner, S., Larhammar, D., and Venkatesh, B. (2009) Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation. Genomics. 93(3):254-260.
Abstract
We describe here the repertoire of neuropeptide Y (NPY) peptides and receptors in the elephant shark Callorhinchus milii, belonging to the chondrichthyans that diverged from the rest of the gnathostome (jawed vertebrate) lineage about 450 million years ago and the first chondrichthyan with a genome project. We have identified two peptide genes that are orthologous to NPY and PYY (peptide YY) in other vertebrates, and seven receptor genes orthologous to the Y1, Y2, Y4, Y5, Y6, Y7 and Y8 subtypes found in tetrapods and teleost fishes. The repertoire of peptides and receptors seems to reflect the ancestral configuration in the predecessor of all gnathostomes, whereas other lineages such as mammals and teleosts have lost one or more receptor genes or have acquired 1-2 additional peptide genes. Both the peptides and receptors showed broad and overlapping mRNA expression which may explain why some receptor gene losses could take place in some lineages, but leaves open the question why all the known ancestral receptors have been retained in the elephant shark.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping