PUBLICATION
Using zebrafish to assess the impact of drugs on neural development and function
- Authors
- Guo, S.
- ID
- ZDB-PUB-090929-5
- Date
- 2009
- Source
- Expert opinion on drug discovery 4(7): 715-726 (Review)
- Registered Authors
- Guo, Su
- Keywords
- zebrafish, neural development, neurodegeneration, function, small molecule drug discovery, neurological disorders, autism, Parkinson’s disease, Alzheimer’s disease, Hungtinton’s disease, anxiety/depression, addiction
- MeSH Terms
- none
- PubMed
- 19774094 Full text @ Expert Opin. Drug Discov.
Citation
Guo, S. (2009) Using zebrafish to assess the impact of drugs on neural development and function. Expert opinion on drug discovery. 4(7):715-726.
Abstract
BACKGROUND: Zebrafish is becoming an increasingly attractive model organism for understanding biology and developing therapeutics, because as a vertebrate, it shares considerable similarity with mammals in both genetic compositions and tissue/organ structures, and yet remains accessible to high throughput phenotype-based genetic and small molecule compound screening. OBJECTIVE/METHOD: The focus of this review is on the nervous system, which is arguably the most complex organ and known to be afflicted by more than six hundred disorders in humans. I discuss the past, present, and future of using zebrafish to assess the impact of small molecule drugs on neural development and function, in light of understanding and treating neurodevelopmental disorders such as autism, neurodegenerative disorders including Alzheimer's, Parkinson's, and Hungtington's disease, and neural system dysfunctions such as anxiety/depression and addiction. CONCLUSION: These studies hold promise to reveal fundamental mechanisms governing nervous system development and function, and to facilitate small molecule drug discovery for the many types of neurological disorders.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping