PUBLICATION
Convergence and extension movements during vertebrate gastrulation
- Authors
- Yin, C., Ciruna, B., and Solnica-Krezel, L.
- ID
- ZDB-PUB-090914-42
- Date
- 2009
- Source
- Current topics in developmental biology 89: 163-192 (Review)
- Registered Authors
- Ciruna, Brian, Solnica-Krezel, Lilianna, Yin, Chunyue
- Keywords
- Bmp, Directed migration, G protein, Intercalation, Mesoderm, Noncanonical Wnt signalling, Oriented cell division, Planar cell polarity, Stat3, Zebrafish
- MeSH Terms
-
- Animals
- Cell Movement*
- Cell Polarity
- Gastrulation/physiology*
- Mesoderm/cytology
- Time Factors
- Vertebrates/embryology*
- PubMed
- 19737646 Full text @ Curr. Top. Dev. Biol.
Citation
Yin, C., Ciruna, B., and Solnica-Krezel, L. (2009) Convergence and extension movements during vertebrate gastrulation. Current topics in developmental biology. 89:163-192.
Abstract
During vertebrate gastrulation, coordinated cell movements shape the basic body plan. Key components of gastrulation are convergence and extension (C&E) movements, which narrow and lengthen the embryonic tissues, respectively. The rates of C&E movements differ significantly according to the position and the stage of gastrulation. Here, we review the distinct cellular behaviors that define the spatial and temporal patterns of C&E movements, with the special emphasis on zebrafish. We also summarize the molecular regulation of these cellular behaviors and the interplay between different signaling pathways that drive C&E. Finally, to ensure efficient C&E movements, cells must achieve mediolaterally-elongated cell morphology and polarize motile protrusions. We discuss the recent discoveries on the molecular and cellular mechanisms by which the mediolateral cell polarity is established.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping