PUBLICATION
Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities
- Authors
- Li, X.L., Li, Y., Wang, S.F., Zhao, Y.L., Liu, K.C., Wang, X.M., and Yang, Y.P.
- ID
- ZDB-PUB-090519-1
- Date
- 2009
- Source
- Journal of natural products 72(6): 1001-1005 (Journal)
- Registered Authors
- Li, Yang
- Keywords
- none
- MeSH Terms
-
- Angiogenesis Inhibitors/chemistry
- Angiogenesis Inhibitors/isolation & purification*
- Angiogenesis Inhibitors/pharmacology*
- Animals
- Crystallography, X-Ray
- Disease Models, Animal
- Diterpenes/chemistry
- Diterpenes/isolation & purification*
- Diterpenes/pharmacology*
- Euphorbia/chemistry*
- Molecular Conformation
- Molecular Structure
- Nuclear Magnetic Resonance, Biomolecular
- Zebrafish
- PubMed
- 19438253 Full text @ J. Nat. Prod.
Citation
Li, X.L., Li, Y., Wang, S.F., Zhao, Y.L., Liu, K.C., Wang, X.M., and Yang, Y.P. (2009) Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities. Journal of natural products. 72(6):1001-1005.
Abstract
Ten new ingol lathyrane-type diterpenes (1-10) and two known ingenol derivatives (11 and 12) were isolated from the aerial parts of Euphorbia royleana. The structures of 1-10 were elucidated on the basis of spectroscopic methods including 2D NMR analysis, and the structure of compound 1 was confirmed by single-crystal X-ray crystallography. Antiangiogenic effects of all compounds except for 5 were tested using a zebrafish model, with compounds 11 and 12 being active in this bioassay.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping