PUBLICATION
Signaling pathways regulating zebrafish lateral line development
- Authors
- Ma, E.Y., and Raible, D.W.
- ID
- ZDB-PUB-090518-11
- Date
- 2009
- Source
- Current biology : CB 19(9): R381-R386 (Review)
- Registered Authors
- Raible, David
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Differentiation/physiology*
- Cell Movement/physiology*
- Fibroblast Growth Factors/metabolism
- Lateral Line System/embryology*
- Lateral Line System/metabolism*
- Morphogenesis/physiology*
- Receptors, Notch/metabolism
- Signal Transduction/physiology*
- Wnt Proteins/metabolism
- Zebrafish/embryology*
- beta Catenin/metabolism
- PubMed
- 19439264 Full text @ Curr. Biol.
Citation
Ma, E.Y., and Raible, D.W. (2009) Signaling pathways regulating zebrafish lateral line development. Current biology : CB. 19(9):R381-R386.
Abstract
The lateral line organ is a mechanosensory organ of fish and amphibians that detects changes in water flow. The lateral line organ of zebrafish has been used as a model for cell polarity and collective cell migration as well as hair cell loss and regeneration. A combination of genetic tools and live imaging has allowed dissection of signaling pathways that regulate these processes. Here, we summarize recent findings on the roles of the FGF, Wnt/beta-catenin, and Notch pathways in the initial formation of the posterior lateral line primordium, as well as during organ patterning, migration, cell fate specification and hair cell regeneration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping