ZFIN ID: ZDB-PUB-090320-1
Noncanonical Wnt Signaling in Tumor Progression and Metastasis
Jessen, J.R.
Date: 2009
Source: Zebrafish   6(1): 21-28 (Review)
Registered Authors: Jessen, Jason R.
Keywords: none
MeSH Terms:
  • Animals
  • Cell Movement
  • Neoplasm Metastasis*
  • Neoplasms/metabolism*
  • Signal Transduction*
  • Wnt Proteins/metabolism*
  • Zebrafish/metabolism*
PubMed: 19292672 Full text @ Zebrafish
For almost 15 years, the concept that noncanonical (beta-catenin-independent) Wnt signaling pathways play key roles in embryonic development has grown steadily in the scientific literature. Significant progress has been made toward understanding how these pathways regulate morphogenetic processes as diverse as gastrulation cell movements and the formation of cilia. More recently, however, data have implicated components of noncanonical Wnt/Ca(2+) and Wnt/planar cell polarity signaling in directly promoting the invasiveness and malignant progression of diverse forms of human cancer. Here I review this emerging field of cancer research using data from developmental model systems to provide a framework for addressing future questions.