PUBLICATION
ccbe1 is required for embryonic lymphangiogenesis and venous sprouting
- Authors
- Hogan, B.M., Bos, F.L., Bussmann, J., Witte, M., Chi, N.C., Duckers, H.J., and Schulte-Merker, S.
- ID
- ZDB-PUB-090319-10
- Date
- 2009
- Source
- Nature Genetics 41(4): 396-398 (Journal)
- Registered Authors
- Bos, Frank, Bussmann, Jeroen, Hogan, Ben M., Schulte-Merker, Stefan, Witte, Merlijn
- Keywords
- none
- MeSH Terms
-
- Amino Acid Substitution
- Animals
- Binding Sites
- Calcium/metabolism
- Cell Division
- Cell Movement
- Embryo, Nonmammalian/physiology
- Embryonic Development
- Epidermal Growth Factor/genetics*
- Humans
- Lymphangiogenesis/genetics*
- Lymphatic Vessels/cytology
- Lymphatic Vessels/embryology
- Lymphatic Vessels/physiology*
- Models, Animal
- Mutation*
- Vascular Endothelial Growth Factor C/genetics
- Zebrafish
- PubMed
- 19287381 Full text @ Nat. Genet.
Citation
Hogan, B.M., Bos, F.L., Bussmann, J., Witte, M., Chi, N.C., Duckers, H.J., and Schulte-Merker, S. (2009) ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nature Genetics. 41(4):396-398.
Abstract
Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping