PUBLICATION

The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications

Authors
Dejana, E., Tournier-Lasserve, E., and Weinstein, B.M.
ID
ZDB-PUB-090217-40
Date
2009
Source
Developmental Cell   16(2): 209-221 (Review)
Registered Authors
Weinstein, Brant M.
Keywords
none
MeSH Terms
  • Animals
  • Antigens, CD/metabolism
  • Binding Sites
  • Cadherins/metabolism
  • Capillary Permeability
  • Cyclic AMP/metabolism
  • Disease Models, Animal
  • Endothelium, Vascular/pathology*
  • Humans
  • Intercellular Junctions/metabolism
  • Mice
  • Mice, Transgenic
  • Models, Biological
  • Phenotype
  • Signal Transduction
  • rap1 GTP-Binding Proteins/metabolism
PubMed
19217423 Full text @ Dev. Cell
Abstract
Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have been associated with defects in the organization of endothelial cell junctions. Understanding the molecular basis of these diseases requires different integrated approaches which include basic cell biology, clinical studies, and studies in animal models such as mice and zebrafish. In this review we discuss recent findings derived from these approaches and their possible integration in a common picture.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes