The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications
- Dejana, E., Tournier-Lasserve, E., and Weinstein, B.M.
- Developmental Cell 16(2): 209-221 (Review)
- Registered Authors
- Weinstein, Brant M.
- MeSH Terms
- Antigens, CD/metabolism
- Binding Sites
- Capillary Permeability
- Cyclic AMP/metabolism
- Disease Models, Animal
- Endothelium, Vascular/pathology*
- Intercellular Junctions/metabolism
- Mice, Transgenic
- Models, Biological
- Signal Transduction
- rap1 GTP-Binding Proteins/metabolism
- 19217423 Full text @ Dev. Cell
Dejana, E., Tournier-Lasserve, E., and Weinstein, B.M. (2009) The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications. Developmental Cell. 16(2):209-221.
Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have been associated with defects in the organization of endothelial cell junctions. Understanding the molecular basis of these diseases requires different integrated approaches which include basic cell biology, clinical studies, and studies in animal models such as mice and zebrafish. In this review we discuss recent findings derived from these approaches and their possible integration in a common picture.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes