ZFIN ID: ZDB-PUB-090217-24
On the diabetic menu: Zebrafish as a model for pancreas development and function
Kinkel, M.D., and Prince, V.E.
Date: 2009
Source: BioEssays : news and reviews in molecular, cellular and developmental biology   31(2): 139-152 (Review)
Registered Authors: Kinkel, Mary, Prince, Victoria E.
Keywords: β-cell, pancreas, patterning, zebrafish
MeSH Terms:
  • Animals
  • Cell Lineage
  • Diabetes Mellitus/embryology*
  • Models, Animal*
  • Pancreas/cytology
  • Pancreas/embryology*
  • Pancreas/metabolism*
  • Regeneration
  • Zebrafish/embryology*
PubMed: 19204986 Full text @ Bioessays
Development of the vertebrate pancreas is a complex stepwise process comprising regionalization, cell differentiation, and morphogenesis. Studies in zebrafish are contributing to an emerging picture of pancreas development in which extrinsic signaling molecules influence intrinsic transcriptional programs to allow ultimate differentiation of specific pancreatic cell types. Zebrafish experiments have revealed roles for several signaling molecules in aspects of this process; for example our own work has shown that retinoic acid signals specify the pre-pancreatic endoderm. Time-lapse imaging of live zebrafish embryos has started to provide detailed information about early pancreas morphogenesis. In addition to modeling embryonic development, the zebrafish has recently been used as a model for pancreas regeneration studies. Here, we review the significant progress in these areas and consider the future potential of zebrafish as a diabetes research model.