ZFIN ID: ZDB-PUB-090209-2
Other model organisms for sarcomeric muscle diseases
Sparrow, J., Hughes, S.M., and Segalat, L.
Date: 2008
Source: Advances in experimental medicine and biology   642: 192-206 (Review)
Registered Authors: Hughes, Simon M.
Keywords: none
MeSH Terms:
  • Animals
  • Cell Differentiation
  • Disease Models, Animal
  • Genome/genetics
  • Humans
  • Muscular Diseases/genetics
  • Muscular Diseases/metabolism*
  • Muscular Diseases/pathology
  • Sarcomeres/metabolism*
PubMed: 19181102 Full text @ Adv. Exp. Med. Biol.
Model organisms are vital to our understanding of human muscle biology and disease. The potential of the nematode Caenorhabditis elegans, the fruitfly, Drosophila melanogaster and the zebrafish, Danio rerio, as model genetic organisms for the study of human muscle disease is discussed by examining their muscle biology, muscle genetics and development. The powerful genetic tools available with each organism are outlined. It is concluded that these organisms have already demonstrated potential in facilitating the study of muscle disease and in screening for therapeutic agents.