PUBLICATION
Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina
- Authors
- Rätscho, N., Scholten, A., and Koch, K.W.
- ID
- ZDB-PUB-090204-14
- Date
- 2009
- Source
- Biochimica et biophysica acta. Molecular cell research 1793(6): 1110-1114 (Journal)
- Registered Authors
- Keywords
- Guanylate cyclase, GCAP, Neuronal calcium sensor protein, Retina
- MeSH Terms
-
- Zebrafish*/anatomy & histology
- Zebrafish*/growth & development
- Zebrafish*/metabolism
- Guanylate Cyclase/genetics
- Guanylate Cyclase/metabolism*
- Protein Isoforms/genetics
- Protein Isoforms/metabolism
- Larva/anatomy & histology
- Larva/metabolism
- Retina/cytology
- Retina/metabolism*
- Gene Expression Profiling
- Animals
- Guanylate Cyclase-Activating Proteins/genetics
- Guanylate Cyclase-Activating Proteins/metabolism*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- Photoreceptor Cells, Vertebrate/cytology
- Photoreceptor Cells, Vertebrate/metabolism
- PubMed
- 19168097 Full text @ BBA Molecular Cell Research
Citation
Rätscho, N., Scholten, A., and Koch, K.W. (2009) Expression profiles of three novel sensory guanylate cyclases and guanylate cyclase-activating proteins in the zebrafish retina. Biochimica et biophysica acta. Molecular cell research. 1793(6):1110-1114.
Abstract
Three membrane bound sensory guanylate cyclases are expressed in photoreceptor cells of the developing and adult zebrafish retina. First appearance of mRNA transcripts was detected by in situ hybridization techniques for all guanylate cyclases between 3 and 4 days post fertilization (dpf), but only one isoform (guanylate cyclase 3) appeared to be specifically expressed in cones of the adult retina. Transcripts of three cone specific guanylate cyclase-activating proteins (zGCAP3, zGCAP4 and zGCAP7) were also detected at 3-4 dpf. The expression onset of the guanylate cyclases and these neuronal calcium sensor proteins mainly overlapped. High guanylate cyclase activities in larval eye preparations and the precisely controlled coexpression of guanylate cyclases and zGCAPs coincide with the onset of visual function at 3-4 dpf.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping