PUBLICATION
The zebrafish as a novel tool for cardiovascular drug discovery
- Authors
- Rocke, J., Lees, J., Packham, I., and Chico, T.
- ID
- ZDB-PUB-090123-8
- Date
- 2009
- Source
- Recent advances in cardiovascular drug discovery 4(1): 1-5 (Review)
- Registered Authors
- Chico, Tim J.
- Keywords
- none
- MeSH Terms
-
- Animals
- Cardiovascular Agents/pharmacology*
- Cardiovascular System/drug effects
- Cardiovascular System/embryology
- Cardiovascular System/growth & development
- Drug Delivery Systems
- Drug Discovery*
- Drug Evaluation, Preclinical
- Models, Animal*
- Zebrafish*/anatomy & histology
- Zebrafish*/embryology
- Zebrafish*/genetics
- Zebrafish*/growth & development
- PubMed
- 19149699 Full text @ Recent Pat. Cardiovasc. Drug Discov.
Citation
Rocke, J., Lees, J., Packham, I., and Chico, T. (2009) The zebrafish as a novel tool for cardiovascular drug discovery. Recent advances in cardiovascular drug discovery. 4(1):1-5.
Abstract
The zebrafish is a well established model of vertebrate development, but has recently emerged as a powerful tool for cardiovascular research and in vivo cardiovascular drug discovery. The zebrafish embryo's low cost, small size and permeability to small molecules coupled with the ability to generate thousands of embryos per week, and improved automation of assays of cardiovascular development and performance allow drug screening for a number of cardiovascular effects. Such studies have already led to discovery of novel cardiovascular drugs with potentially clinically beneficial effects. In this review we summarise the advantages and disadvantages of the zebrafish for drug discovery using some patents, previous literature on zebrafish-based drug screening and assess where the zebrafish will fit into existing drug discovery programmes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping