PUBLICATION
Emergence of binocular functional properties in a monocular neural circuit
- Authors
- Ramdya, P., and Engert, F.
- ID
- ZDB-PUB-090123-20
- Date
- 2008
- Source
- Nature Neuroscience 11(9): 1083-1090 (Journal)
- Registered Authors
- Engert, Florian
- Keywords
- none
- MeSH Terms
-
- Amino Acids
- Animals
- Animals, Genetically Modified
- Calcium/metabolism
- Embryo, Nonmammalian
- Functional Laterality/genetics
- Functional Laterality/physiology*
- In Vitro Techniques
- Larva
- Microphthalmia-Associated Transcription Factor/deficiency
- Photic Stimulation/methods
- Sensory Deprivation
- Sensory Receptor Cells/classification
- Sensory Receptor Cells/physiology*
- Superior Colliculi/physiology*
- Time Factors
- Vision, Binocular/genetics
- Vision, Binocular/physiology*
- Visual Fields/genetics
- Visual Fields/physiology*
- Visual Pathways/physiology
- Zebrafish
- Zebrafish Proteins/deficiency
- PubMed
- 19160507 Full text @ Nat. Neurosci.
Citation
Ramdya, P., and Engert, F. (2008) Emergence of binocular functional properties in a monocular neural circuit. Nature Neuroscience. 11(9):1083-1090.
Abstract
Sensory circuits frequently integrate converging inputs while maintaining precise functional relationships between them. For example, in mammals with stereopsis, neurons at the first stages of binocular visual processing show a close alignment of receptive-field properties for each eye. Still, basic questions about the global wiring mechanisms that enable this functional alignment remain unanswered, including whether the addition of a second retinal input to an otherwise monocular neural circuit is sufficient for the emergence of these binocular properties. We addressed this question by inducing a de novo binocular retinal projection to the larval zebrafish optic tectum and examining recipient neuronal populations using in vivo two-photon calcium imaging. Notably, neurons in rewired tecta were predominantly binocular and showed matching direction selectivity for each eye. We found that a model based on local inhibitory circuitry that computes direction selectivity using the topographic structure of both retinal inputs can account for the emergence of this binocular feature.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping