|ZFIN ID: ZDB-PUB-090123-20|
Emergence of binocular functional properties in a monocular neural circuit
Ramdya, P., and Engert, F.
|Source:||Nature Neuroscience 11(9): 1083-1090 (Journal)|
|Registered Authors:||Engert, Florian|
|PubMed:||19160507 Full text @ Nat. Neurosci.|
Ramdya, P., and Engert, F. (2008) Emergence of binocular functional properties in a monocular neural circuit. Nature Neuroscience. 11(9):1083-1090.
ABSTRACTSensory circuits frequently integrate converging inputs while maintaining precise functional relationships between them. For example, in mammals with stereopsis, neurons at the first stages of binocular visual processing show a close alignment of receptive-field properties for each eye. Still, basic questions about the global wiring mechanisms that enable this functional alignment remain unanswered, including whether the addition of a second retinal input to an otherwise monocular neural circuit is sufficient for the emergence of these binocular properties. We addressed this question by inducing a de novo binocular retinal projection to the larval zebrafish optic tectum and examining recipient neuronal populations using in vivo two-photon calcium imaging. Notably, neurons in rewired tecta were predominantly binocular and showed matching direction selectivity for each eye. We found that a model based on local inhibitory circuitry that computes direction selectivity using the topographic structure of both retinal inputs can account for the emergence of this binocular feature.