PUBLICATION
Zwilling-A and -B, two related myelin proteins of teleosts, which originate from a single, bicistronic transcript
- Authors
- Schaefer, K., and Brösamle, C.
- ID
- ZDB-PUB-090112-6
- Date
- 2009
- Source
- Mol. Biol. Evol. 26(3): 495-499 (Journal)
- Registered Authors
- Brösamle, Christian, Schaefer, Karin
- Keywords
- myelin, evolution, zebrafish, genome duplication
- MeSH Terms
-
- Animals
- Evolution, Molecular
- Genomics
- Myelin Proteins/genetics*
- Neural Crest/chemistry
- Neuroglia/chemistry
- Phylogeny
- RNA, Messenger*
- Zebrafish
- Zebrafish Proteins/genetics*
- PubMed
- 19126863 Full text @ Mol. Biol. Evol.
Citation
Schaefer, K., and Brösamle, C. (2009) Zwilling-A and -B, two related myelin proteins of teleosts, which originate from a single, bicistronic transcript. Mol. Biol. Evol.. 26(3):495-499.
Abstract
Myelination, the ensheathment of axons by membranes of highly specialized glial cells, has been a crucial innovation during early vertebrate evolution. It enables high nerve signal conduction velocities, while maintaining nervous system size and energy requirements at moderate levels. Consequently, myelination has been conserved in all extant gnathostome vertebrates. In a genome-wide mRNA expression screen, we identified several novel neural crest and myelin-specific transcripts in the zebrafish (Danio rerio). Here, we describe the characterization of two proteins, Zwilling-A and -B, which are exclusively expressed in myelinating glia of teleosts. They are structurally homologous and are translated from a common, bicistronic transcript. No similarities to sequences or domains of other proteins were detected. Analysis of phylogeny, genomic organization, and genomic syntenies suggests that the zwi gene has appeared soon after the teleost-specific genome duplication event and evolved under conservative selective pressure. We hypothesize that Zwilling-A and -B serve important physiological functions in teleost myelin.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping