ZFIN ID: ZDB-PUB-080915-22
Melanocytes in Development, Regeneration, and Cancer
White, R.M., and Zon, L.I.
Date: 2008
Source: Cell Stem Cell   3(3): 242-252 (Review)
Registered Authors: White, Richard M., Zon, Leonard I.
Keywords: none
MeSH Terms:
  • Animals
  • Humans
  • Melanocytes/cytology
  • Melanocytes/physiology*
  • Melanoma/physiopathology*
  • Regeneration*
  • Stem Cells/cytology
  • Stem Cells/physiology
PubMed: 18786412 Full text @ Cell Stem Cell
The genes required for stem cell specification and lineage restriction during embryogenesis also play fundamental roles in adult tissue regeneration and cancer. This "development-regeneration-cancer" axis is exemplified by the vertebrate pigmentation system. Melanocytes exhibit almost unlimited self-renewal capacity during regenerative processes such as mammalian hair recoloration and zebrafish fin regeneration. Melanoma utilizes many regulatory signals and pathways required during ontogeny and regeneration. A discussion of these interconnections highlights how studies of stem cell function in embryonic and regenerative contexts can yield insights into melanoma biology.