ZFIN ID: ZDB-PUB-080908-17
Role of p53 family in birth defects: Lessons from zebrafish
Danilova, N., Sakamoto, K.M., and Lin, S.
Date: 2008
Source: Birth defects research. Part C, Embryo today : reviews   84(3): 215-227 (Review)
Registered Authors: Danilova, Nadia, Lin, Shuo
Keywords: zebrafish, p53, p63, p73, congenital abnormalities
MeSH Terms:
  • Animals
  • Congenital Abnormalities/genetics*
  • Embryo, Nonmammalian/abnormalities*
  • Embryo, Nonmammalian/metabolism
  • Embryo, Nonmammalian/radiation effects
  • Gene Expression Regulation, Developmental/genetics
  • Gene Expression Regulation, Developmental/radiation effects
  • Protein Isoforms/genetics
  • Protein Isoforms/metabolism
  • Tumor Suppressor Protein p53/genetics
  • Tumor Suppressor Protein p53/metabolism*
  • Zebrafish/embryology
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 18773461 Full text @ Birth Defects Res. C Embryo Today
p53 protein family is an important teratologic suppressor, but in certain conditions it can cause congenital abnormalities. p53 family performs this dual role in development by integrating information from cell's interior with that from the environment to determine the choice between life and death. Understanding of p53 family developmental functions may lead to new therapeutic approaches for treatment and prevention of birth defects. Zebrafish is becoming the vertebrate system of choice for studying p53 family role in development.