PUBLICATION
Divergence of regulatory sequences in duplicated fish genes
- Authors
- Hellemont, R.V., Blomme, T., Van de Peer, Y., and Marchal, K.
- ID
- ZDB-PUB-080902-23
- Date
- 2007
- Source
- Genome dynamics 3: 81-100 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Base Sequence
- Consensus Sequence
- DNA, Intergenic/genetics
- Databases, Genetic
- Fishes/genetics*
- Genes, Duplicate*
- Genetic Variation*
- Molecular Sequence Data
- Regulatory Sequences, Nucleic Acid/genetics*
- Sequence Homology, Nucleic Acid
- PubMed
- 18753786 Full text @ Genome Dyn.
Citation
Hellemont, R.V., Blomme, T., Van de Peer, Y., and Marchal, K. (2007) Divergence of regulatory sequences in duplicated fish genes. Genome dynamics. 3:81-100.
Abstract
Duplicated genes can undergo different fates, from nonfunctionalization to subfunctionalization and neofunctionalization. In particular, changes in regulatory sequences affecting the expression domain of genes seem to be responsible for the latter two fates. In this study we used in silico motif detection to show how alterations in the composition of regulatory motifs between paralogous genes in zebrafish and Tetraodon might reflect the functional divergence of duplicates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping