PUBLICATION

New regulators of vertebrate appendage regeneration

Authors
Yin, V.P., and Poss, K.D.
ID
ZDB-PUB-080728-4
Date
2008
Source
Current opinion in genetics & development   18(4): 381-386 (Review)
Registered Authors
Poss, Kenneth D., Yin, Voot
Keywords
none
MeSH Terms
  • Amphibian Proteins/pharmacology
  • Animals
  • Extremities/physiology
  • Gene Expression Regulation/drug effects*
  • Gene Expression Regulation/physiology
  • MicroRNAs/physiology
  • Mitogens/pharmacology*
  • Models, Biological
  • Nerve Tissue/drug effects
  • Nerve Tissue/physiology
  • Regeneration/drug effects*
  • Regeneration/genetics*
  • Regeneration/physiology
  • Salamandridae/physiology
  • Vertebrates/genetics
  • Vertebrates/physiology*
  • Zebrafish/genetics
  • Zebrafish/physiology
PubMed
18644447 Full text @ Curr. Opin. Genet. Dev.
Abstract
Appendage regeneration is a complex and fascinating biological process exhibited in vertebrates by urodele amphibians and teleost fish. A current focus in the field is to identify new molecules that control formation and function of the regeneration blastema, a mass of proliferative mesenchyme that emerges after limb or fin amputation and serves as progenitor tissue for lost structures. Two studies published recently have illuminated new molecular regulators of blastemal proliferation. After amputation of a newt limb, the nerve sheath releases nAG, a blastemal mitogen that facilitates regeneration. In amputated zebrafish fins, regeneration is optimized through depletion of the microRNA miR-133, a mechanism that requires Fgf signaling. These discoveries establish research avenues that may impact the regenerative capacity of mammalian tissues.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping