ZFIN ID: ZDB-PUB-080710-1
Differentiation of the vertebrate retina is coordinated by an FGF signaling center
Martinez-Morales, J.R., Del Bene, F., Nica, G., Hammerschmidt, M., Bovolenta, P., and Wittbrodt, J.
Date: 2005
Source: Developmental Cell   8(4): 565-574 (Journal)
Registered Authors: Del Bene, Filippo, Hammerschmidt, Matthias, Nica, Gabriela
Keywords: none
MeSH Terms:
  • Animals
  • Cell Differentiation/physiology*
  • Chick Embryo
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/metabolism*
  • In Situ Hybridization
  • Morphogenesis/physiology
  • Retina/cytology*
  • Retina/growth & development*
  • Retina/metabolism
  • Signal Transduction/physiology*
  • Zebrafish/embryology
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 15809038 Full text @ Dev. Cell
In vertebrates, midline-derived sonic hedgehog and nodal are crucial for the initial proximal-distal patterning of the eye. The establishment of the distal optic stalk is in turn a prerequisite to initiate retinogenesis. However, the signal that activates this process is unknown. Here, we demonstrate that in both chick and fish, the initiation of retinal differentiation is triggered by a species-specific localized Fgf signaling center that acts as mediator of the midline signals. The concerted activity of Fgf8 and Fgf3 is both necessary and sufficient to coordinate retinal differentiation independent of the connecting optic stalk.