PUBLICATION
Conserved non-coding sequences and transcriptional regulation
- Authors
- Strähle, U., and Rastegar, S.
- ID
- ZDB-PUB-080520-3
- Date
- 2008
- Source
- Brain research bulletin 75(2-4): 225-230 (Review)
- Registered Authors
- Rastegar, Sepand, Strähle, Uwe
- Keywords
- Cis element, Transcription factor, Transcriptional regulation, Conserved non-coding sequences, Sonic hedgehog, Neurogenin1, Zebrafish, Mouse
- MeSH Terms
-
- Animals
- Conserved Sequence*
- Evolution, Molecular*
- Gene Expression Regulation/physiology*
- Hedgehogs/physiology
- Transcription, Genetic/physiology*
- PubMed
- 18331875 Full text @ Brain Res. Bull.
Citation
Strähle, U., and Rastegar, S. (2008) Conserved non-coding sequences and transcriptional regulation. Brain research bulletin. 75(2-4):225-230.
Abstract
Genes coding for transcription factors and developmental regulators have a high likelihood to harbour cis-regulatory regions that are structurally conserved among orthologous genes in the vertebrate lineage. These regions can span up to several hundred basepairs with 70 and more percent sequence identity between fish and mammals. Even though this conservation is an efficient tool to discover cis-regulatory regions, we know little about why these specific genes maintain such highly conserved regulatory sequences. Here, we summarise work of the past few years on the regulatory modules of the sonic hedgehog and neurogenin1 genes. We will discuss the high sequence conservation of the regulatory elements in the context of models of enhancer evolution. Our data suggest that conservation of sequence does not necessarily imply a conserved function in other vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping